Understanding Drug Release and Absorption Mechanisms
| Series: | |
| Publisher: | Taylor & Francis |
| Subject: | Pharmacokinetics--Mathematical models, Drugs--Solubility--Mathematical models, Drugs--Absorption and adsorption--Mathematic, Drugs--Controlled release--Mathematical mode, Pharmacokinetics, Models, Theoretical, Pharmaceutical Preparations--metabolism |
| Pages: | 627 pages |
| Binding: | Hardcover |
| ISBN: | 9780849330872 |
| Call No: | RM 301.5 U53 2007 |
Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding of all elements needed to conceive, build, and implement successful models of drug release.
Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, micro emulsions, and permeability through membranes.