Photoreceptors and Calcium
| Series: | |
| Publisher: | Springer Science & Business Media |
| Subject: | Retina, Calcium--Physiological effect. |
| Authors: | Wolfgang Baehr , Krzysztof Palczewski |
| Pages: | 625 pages |
| Binding: | Hardcover |
| ISBN: | 9781461501213 |
| Call No: | QP 479.P467 2002 |
This volume focuses on the status of Ca2+ ions in the regulation of phototransduction, light adaptation, and the recovery phase in vertebrate photoreceptors. Particular emphasis is given to Ca2+-binding proteins and their targets, among them particulate guanylate cyclases, GPCR-coupled kinases and cyclic nucleotide-gated cation channels. The book also expands our understanding of events involving Ca2+ in the retinal pigment epithelium, in synaptic transmission and in secondary retinal neurons. A significant part of the book is dedicated to the role of Ca2+ in invertebrate phototransduction, the best-studied phospholipid-mediated signal transduction pathway. Several chapters explore the association of gene defects with human retina disease and the generation of animal models of retinal degeneration.