Evaluation of Enzyme Inhibitors in Drug Discovery
| Series: | |
| Publisher: | Wiley |
| Subject: | Enzyme inhibitors-Therapeutic use-Testing, Drugs-Design, Enzyme inhibitors-Structure-activity relatio |
| Authors: | Robert A. Copeland |
| Pages: | 300 pages |
| Binding: | Hardcover |
| ISBN: | 9780471686965 |
| Call No: | QP 601.5 C782 2005 |
Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted.
This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.