Pharmacokinetic profiling in drug research biological, physicochemical, and computational strategies
| Series: | |
| Publisher: | Weinheim : Wiley-VCH |
| Subject: | Pharmacokinetics, Drugs--Research, Chemistry, Pharmaceutical, Lipids--Chemistry, Pharmacokinetics, Research--Methods |
| Authors: | Bernard Testa |
| Pages: | 299 pages |
| Binding: | Hardcover |
| ISBN: | 9783906390352 |
| Call No: | RM 301.5 P536 2004 |
Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of 'hits', which invade the databases like swarms of locusts. But far from being a plague, these innumerable compounds become a blessing if properly screened for 'drug ability', i.e., for 'drug-like' properties such as good pharmacokinetic (PK) behavior. Pharmacokinetic profiling of bioactive compounds has, thus, become a sine qua non condition for cherry-picking the most promising hits. Just as important, but less visible, are the structure-property and structure-ADME relations, which emerge from PK profiling and provide useful feedback when designing new synthetic series.